Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function
C. Chang, S. L. Banerjee, S. S. Park, X. Zhang, D. Cotnoir-White, K. J. Opperman, M. Desbois, B. Grill, A. Kania
This study identifies MYCBP2 as a critical ubiquitin ligase that stabilizes EPHB2 and facilitates its signaling function through interactions with FBXO45 and ephrin-B ligands.
bioRxiv · Jun 12, 2023Cell Biology