Author

M. Reglinski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

H. C. Dorfmueller· 2 shared S. Ajay Castro· 2 shared S. Sriskandan· 2 shared S. Thomson· 2 shared A. Fosberry· 1 shared A. Ruda· 1 shared A. Zorzoli· 1 shared B. H. Meyer· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

H. C. Dorfmueller

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A platform for the recombinant production of Group A Streptococcus glycoconjugate vaccines

S. Ajay Castro, I. J. Passmore, D. Ndeh, H. A. Shaw, A. Ruda, K. Burns, S. Thomson, R. Nagar, K. Alagesan, K. Lucas, S. Abouelhadid, M. Reglinski, U. Schwarz- Linek, F. Mawas, G. Widmalm, , H. C. Dorfmueller

This study develops a platform for recombinant production of Group A Streptococcus glycoconjugate vaccines using E. coli, confirming their structural integrity and immunogenicity in animal models.

bioRxiv · Mar 1, 2024Microbiology

Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

M. Pearson, C. Haslam, A. Fosberry, E. J. Jones, M. Reglinski, R. J. Edwards, R. A. Lawrenson, J. C. Brown, D. Mossakowska, J. E. Pease, S. Sriskandan

This study investigates SpyCEP's enzymatic function, revealing the C-terminal's role in substrate binding and the N-terminal's necessity for full catalytic activity.

bioRxiv · Nov 14, 2021 · PreprintMicrobiology

Recombinant Group A Carbohydrate backbone embedded into Outer Membrane Vesicles is a potent vaccine candidate targeting Group A Streptococcus from Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

S. Ajay Castro, S. Thomson, A. Zorzoli, B. H. Meyer, M. Reglinski, H. C. Dorfmueller

This study demonstrates that recombinant polyrhamnose (pRha) embedded in outer membrane vesicles (OMVs) induces potent antibodies against Group A Streptococcus, effectively killing hypervirulent strains.

bioRxiv · Nov 12, 2021 · PreprintMicrobiology

Vaccine-induced, but not natural immunity, against the Streptococcal Inhibitor of Complement protects against invasive disease

L. K. K. Tan, M. Reglinski, D. Teo, N. Reza, L. E. M. Lamb, V. Nageshwaran, C. E. Turner, M. Wikstroem, I.-M. Frick, L. Bjorck, S. Sriskandan

This study shows that vaccine-induced antibodies against SIC provide protection against invasive S. pyogenes infection, while natural antibodies do not.

bioRxiv · Nov 22, 2020Microbiology