Integration of Patient-Derived Organoids and Organ-on-Chip Systems: Investigating Colorectal Cancer Invasion within the Mechanical and GABAergic Tumor Microenvironment
C. Strelez, R. Perez, J. S. Chlystek, C. Cherry, A. Y. Yoon, B. Haliday, C. Shah, K. Ghaffarian, R. X. Sun, H. Jiang, R. Lau, A. Schatz, H.-J. Lenz, J. E. Katz, S. M. Mumenthaler
This paper combines patient-derived organoids with a microfluidic organ-on-chip system to study colorectal cancer invasion under mechanical and GABAergic influences, showing enhanced invasiveness in KRAS mutant tumors.
bioRxiv · Sep 14, 2023 · PreprintCancer Biology