H. Jiang

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

Membranous translation platforms in the chloroplast of Chlamydomonas reinhardtii

The paper identifies two distinct membranous platforms in chloroplasts of Chlamydomonas reinhardtii involved in translation and thylakoid membrane biogenesis during chloroplast development.

Design of intrinsically disordered region binding proteins

The paper designs proteins that bind intrinsically disordered regions with high affinity and specificity across diverse targets.

BOOST: a robust ten-fold expansion method on hour-scale

BOOST is a rapid expansion microscopy method that achieves ~10x linear expansion in 90 minutes using microwave-assisted chemistry, improving throughput for various biological specimens.

IsRNAcirc: 3D structure prediction of circular RNAs based on coarse-grained molecular dynamics simulation

IsRNAcirc predicts circular RNA 3D structures using coarse-grained molecular dynamics, outperforming template-based methods on a validation set.

Inhibition of serine racemase prevents diabetic retinopathy

This study shows that inhibiting serine racemase with L-ABH prevents diabetic retinopathy by protecting retinal cells and maintaining glucose homeostasis in diabetic mice.

RNA interactome of hypervirulent Klebsiella pneumoniae reveals a small RNA inhibitor of capsular mucoviscosity and virulence

This study identifies ArcZ as a small RNA inhibitor of capsular hypermucoviscosity and virulence in hypervirulent Klebsiella pneumoniae through RNA interactome profiling.

FKBP11 targeted plasma cells promote abdominal aortic aneurysm progression through an m6A-dependent mechanism

This study identifies FKBP11's role in AAA progression via m6A-dependent mechanisms using multi-omics and machine learning.

Frequency-dependence in multidimensional diffusion-relaxation correlation MRI of the brain: overfitting or meaningful parameter?

This study investigates whether frequency-dependent diffusion-relaxation MRI can provide meaningful information or if it leads to overfitting in different tissue types and frequency ranges.

Delta-5 elongase knockout reduces DHA and TAG synthesis coupled with an increase of heat sensitivity in a marine diatom

This study shows that knocking out delta-5 elongase in a marine diatom reduces DHA and TAG synthesis and increases heat sensitivity.

Tetraspanin-enriched microdomains play an important role in pathogenesis in the protozoan parasite Entamoeba histolytica

This study investigates the role of TSPANs in Entamoeba histolytica, showing their involvement in protease secretion and adhesion through protein interactions.

Deep postnatal phenotyping of a new mouse model of nonketotic hyperglycinemia

This paper describes a new mouse model of nonketotic hyperglycinemia with postnatal abnormalities in glycine levels, neural tube defects, body weight, electroencephalographic recordings, and activity, useful for evaluating new therapies.

Screening and characterization of 133 physiologically-relevant environmental chemicals for reproductive toxicity

The paper screens 133 chemicals for reproductive toxicity using C. elegans assays and compares results with ToxCast data, identifying 13 toxicants including QACs.

Structural Requirements for Activity of Mind bomb1 in Notch Signaling

This study identifies the structural requirements of MIB1 for ubiquitin transfer in Notch signaling, showing that RING3 is essential for catalytic activity and dimerization.

Cryo-EM structures of human cone visual pigments

This study presents cryo-EM structures of human cone visual pigments in complex with G proteins, revealing their active state and mutations affecting spectral tuning.

PHOSPHATE-INDUCED 1 and its paralogs positively regulate cellulose biosynthesis in Arabidopsis.

This study shows that PHOSPHATE-INDUCED 1 and its paralogs regulate cellulose biosynthesis in Arabidopsis by modulating CSC activity in response to developmental and environmental cues.

Mitochondrial uncoupler and retinoic acid synergistically induce differentiation and inhibit proliferation in neuroblastoma

Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors

This study identifies XAP5 and XAP5L as antagonistic transcription factors that regulate ciliary gene expression during spermatogenesis, with XAP5 promoting and XAP5L inhibiting ciliary transcription factors at different stages.

Cryo-EM structure and biochemical analysis of human chemokine receptor CCR8

The paper determines the cryo-EM structure of ligand-free human CCR8-Gi complex and identifies key residues for agonist recognition.

An ancient transcription activator is required for the multiciliogenesis program

This study identifies Edf1 as an essential transcription activator for multiciliogenesis, showing its role in ciliary gene expression and its impact on hydrocephalus in mice.

Dissecting the Impact of Maternal Androgen Exposure on Offspring Health through Targeting the Androgen Receptor in Developmental Programming

This study investigates how maternal androgen exposure affects placental development in a PCOS-like mouse model and identifies trophoblast dysfunction as a key mechanism.

Nuclear cytoophidia assembly represses transcriptional activity to control skeletal development and homeostasis

This study identifies nuclear cytoophidia as regulators of Impdh2 transcriptional activity, impacting skeletal development and homeostasis through effects on endochondral ossification and osteoclast function.

Mechanical Resistance to Micro-Heart Tissue Contractility unveils early Structural and Functional Pathology in iPSC Models of Hypertrophic Cardiomyopathy

This study uses iPSC-derived heart tissue models to show that mechanical stress exacerbates HCM-linked MYBPC3 mutations, leading to structural and functional cardiac pathology.

Latitude-Driven Functional Trait Variations in Zizania latifolia: Insights into Climate Adaptation

This study transplants Zizania latifolia populations across latitudes to assess climate adaptation, finding high-latitude populations grow smaller and low-latitude populations lack sexual reproduction, suggesting limited adaptability to global warming.

Integrin-like adhesin CglD confers traction and stabilizes bacterial focal adhesions involved in myxobacterial gliding motility

The paper identifies CglD as a β-integrin-like adhesin in Myxococcus xanthus that stabilizes bacterial focal adhesions and enables gliding motility through mechanosensory and mechanotransductory functions.

Deletion of CD44 promotes adipogenesis by regulating PPARγ and cell cycle-related pathways

This study shows that deleting CD44 in preadipocytes promotes adipogenesis by suppressing PPARγ and cell cycle pathways, suggesting CD44 as a therapeutic target for obesity-related metabolic diseases.

Aquaporin 1 confers apoptosis resistance in pulmonary arterial smooth muscle cells from the SU5416 hypoxia rat model

Integration of Patient-Derived Organoids and Organ-on-Chip Systems: Investigating Colorectal Cancer Invasion within the Mechanical and GABAergic Tumor Microenvironment

This paper combines patient-derived organoids with a microfluidic organ-on-chip system to study colorectal cancer invasion under mechanical and GABAergic influences, showing enhanced invasiveness in KRAS mutant tumors.

Hormonal and transcriptomic analysis reveals the role of ABA and BR in breaking the barrier of inter-subgeneric hybridization in water lily (Nymphaea)

This study identifies ABA and BR as key regulators in overcoming inter-subgeneric hybridization barriers in water lily through transcriptomic and hormonal analyses.

De novo design of buttressed loops for sculpting protein functions

This paper designs proteins with structured loops supported by hydrogen bonds, demonstrating their stability and functionality in binding extended peptides.