R. Perez

Adsorption-driven deformation and landing-footprints of the RBD proteins in SARS-CoV-2 variants onto biological and inanimate surfaces

This study examines how RBD mutations in SARS-CoV-2 affect adsorption to hydrophobic and hydrophilic surfaces, revealing structural deformations and distinct landing-footprints.

Highly pathogenic avian influenza H5N1 virus infections in pinnipeds and seabirds in Uruguay: a paradigm shift to virus transmission in South America

The paper identifies clade 2.3.4.4b H5N1 influenza strains in pinnipeds and seabirds in Uruguay, suggesting mammal-to-mammal and seabird transmission routes in South America.

Systematic comparison of Amber force fields for the mechanical properties of double-stranded DNA

The paper compares the mechanical properties of double-stranded DNA predicted by different force fields under external stress.

Integration of Patient-Derived Organoids and Organ-on-Chip Systems: Investigating Colorectal Cancer Invasion within the Mechanical and GABAergic Tumor Microenvironment

This paper combines patient-derived organoids with a microfluidic organ-on-chip system to study colorectal cancer invasion under mechanical and GABAergic influences, showing enhanced invasiveness in KRAS mutant tumors.

Semi-synthetic CoA-alpha-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies

This study creates a semi-synthetic inhibitor of NatB using coenzyme A and full-length alpha-synuclein, revealing structural and conformational changes upon binding.

Major axes of variation in tree demography across global forests

This study identifies key sources of variation in tree demography across global forests using a variance partitioning framework, finding species differences as a major driver of demographic variance.

Accurate sequence-dependent coarse-grained model for conformational and elastic properties of double-stranded DNA

The paper introduces MADna, a sequence-dependent coarse-grained model of dsDNA that accurately captures conformational and elastic properties, matching atomistic simulations and experimental data.

Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19

The paper examines IFN-I autoantibodies in critical COVID-19 patients through longitudinal single-cell analysis, revealing suppressed ISG-I responses in myeloid cells.

SARS-CoV-2 RBD-Tetanus toxoid conjugate vaccine induces a strong neutralizing immunity in preclinical studies

Lifetime genealogical divergence within plants leads to epigenetic mosaicism in the long lived shrub Lavandula latifolia (Lamiaceae)

This study shows that epigenetic mosaicism in Lavandula latifolia shrubs results from steady lifetime genealogical divergence rather than recent modifications.

Principal component analysis of RNA-seq data unveils a novel prostate cancer-associated gene expression signature

The paper uses PCA on RNA-seq data to identify a gene expression signature associated with prostate cancer, revealing potential biomarkers and molecular alterations.

Double-stranded RNA bending by AU-tract sequences

The paper identifies AU-tracts in dsRNA that cause structural bending through molecular dynamics simulations and AFM experiments.

Understanding the paradoxical mechanical response of in-phase A-tracts at different force regimes

This study investigates the mechanical behavior of A-tracts across different force regimes using single-molecule experiments and polymer models, revealing intrinsic bending and unusual stiffness.

DNA crookedness regulates DNA mechanical properties at short length scales

The paper quantifies DNA crookedness and shows it correlates with DNA stiffness, linking sequence structure to mechanical properties and gene expression.