Comparative Molecular Genomic Analyses of a Spontaneous Rhesus Macaque Model of Mismatch Repair-Deficient Colorectal Cancer
N. Ozirmak Lermi, S. B. Gray, C. M. Bowen, L. Reyes-Uribe, B. K. Dray, N. Deng, R. A. Harris, M. Raveendran, F. Benavides, C. L. Hodo, M. W. Taggart, K. Colbert Maresso, K. M. Sinha, J. Rogers, E. Vilar
This study characterizes a spontaneous MMRd CRC model in rhesus macaques, finding high MSI levels and gene expression patterns similar to human CRC, supporting their use as an animal model.
bioRxiv · Aug 19, 2021 · PreprintCancer Biology