The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope
B. Miglioranza Scavuzzi, V. van Drongelen, B. Kaur, J. Callahan Fox, J. Liu, R. A. Mesquita-Ferrari, J. M. Kahlenberg, E. A. Farkash, F. Benavides, F. W. Miller, A. Sawalha, J. Holoshitz
This study identifies a DRB1*03:01-encoded epitope that drives a lupus-like transcriptome and cellular aberrations in macrophages, revealing a noncanonical mechanism of HLA-disease association in SLE.
bioRxiv · May 31, 2022 · PreprintImmunology