Extra-islet expression of islet antigen boosts T-cell exhaustion to prevent autoimmune diabetes
C. Selck, G. Jhala, D. De George, C.-T. J. Kwong, M. K. Christensen, E. Pappas, X. Liu, T. Ge, P. Trivedi, A. Kallies, H. Thomas, T. W. H. Kay, B. Krishnamurthy
This study shows that extra-islet antigen exposure leads to T-cell exhaustion, which prevents autoimmune diabetes in NOD mice.
bioRxiv · Feb 12, 2023 · PreprintImmunology