H. Thomas

Optimised proteomic analysis of insulin granules from MIN6 β-cells identifies Scamp3, a novel regulator of insulin secretion and content

This study identifies 211 proteins associated with insulin secretory granules in MIN6 β-cells, including SCAMP3, which regulates insulin storage and secretion.

CZ CELLxGENE Discover: A single-cell data platform for scalable exploration, analysis and modeling of aggregated data

CZ CELLxGENE Discover provides a platform for scalable exploration and analysis of aggregated single-cell transcriptomic data across multiple studies.

Tuberculosis susceptibility in genetically diverse mice reveals functional diversity of neutrophils

The paper identifies a novel neutrophil signature associated with poor tuberculosis control in genetically diverse mice.

The impacts of contemporary logging after 250 years of deforestation and degradation on forest-dependent threatened species

This study quantifies historical and contemporary impacts of deforestation and logging on forest-dependent threatened species in New South Wales, showing significant habitat loss and degradation.

Extra-islet expression of islet antigen boosts T-cell exhaustion to prevent autoimmune diabetes

This study shows that extra-islet antigen exposure leads to T-cell exhaustion, which prevents autoimmune diabetes in NOD mice.

Integrated PET and confocal imaging informs a functional timeline for the dynamic process of vascular reconnection during grafting.

This paper uses integrated PET and confocal imaging to establish a spatiotemporal timeline for vascular reconnection during grafting in tomato.

Inhibition of Phosphodiesterase 12 results in Antiviral Activity against several RNA Viruses including SARS-CoV-2.

The paper shows that PDE12 inhibitors increase RNAseL activity and inhibit replication of multiple RNA viruses including SARS-CoV-2 in vitro and in vivo.

Anatomical and biophysical characterization of intergeneric graft-incompatibility within the Solanoideae

This study investigates graft compatibility between four Solanoideae species, finding that only tomato and eggplant heterografts are fully compatible, while others show delayed incompatibility.

Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR

This paper identifies a macrocycle that stabilizes the 14-3-3/CFTR complex, enhancing CFTR membrane localization and activity, particularly for the F508del mutation.

Elevated Neuropeptide Y1 Receptor Signaling Contributes to β-cell Dysfunction and Failure in Type 2 Diabetes

This study shows that increased neuropeptide Y1 receptor signaling contributes to β-cell dysfunction in type 2 diabetes and that inhibiting this receptor with BIBO3304 improves β-cell function and glycaemic control.

SARS-CoV-2 comprehensive receptor profiling: mechanistic insight to drive new therapeutic strategies

The paper screens SARS-CoV-2 spike protein interactions with human cell surface receptors, identifying novel binding proteins and confirming known ones, to inform therapeutic strategies.

Gene regulatory networks for compatible versus incompatible grafts identify a role for SlWOX4 during junction formation

The paper identifies SlWOX4 as a key regulator in tomato grafting by comparing gene regulatory networks of compatible and incompatible grafts.

Platelet Derived Growth Factor Receptor β (PDGFRβ) is a Host Receptor for the human malaria parasite adhesin TRAP

The paper identifies hPDGFRβ as a host receptor for the malaria parasite TRAP, showing its role in sporozoite motility and infection.

Replacing murine insulin 1 with human insulin protects NOD mice from diabetes

This study replaces murine insulin 1 with human insulin in NOD mice, reducing diabetes incidence and showing protective effects against autoimmune responses.