The antimicrobial peptide cathelicidin is critical for the development of Th17 responses in severe inflammatory disease
K. J. Smith, D. Minns, B. McHugh, R. Holloway, R. O'Connor, A. Williams, L. Melrose, R. McPherson, V. E. Miron, D. J. Davidson, E. Gwyer Findlay
This study shows cathelicidin promotes Th17 responses and severe EAE by enhancing T cell differentiation and plasticity, and its absence protects mice from disease.
bioRxiv · Jan 27, 2022 · PreprintImmunology