Author

K. Labib

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Cell Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:drug response / drug discovery· 5 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Assay:proteomics· 3 Organism:C. elegans· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. Canal· 5 shared F. Weissmann· 5 shared J. F. Diffley· 5 shared M. Howell· 5 shared M. Wu· 5 shared R. Beale· 5 shared R. Fujisawa· 5 shared R. Ulferts· 5 shared

Activity by Year

2017-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersBiochemistry

B. Canal

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

O. Raimi, H. Ojha, K. Ehses, V. Dederer, S. Lange, C. P. Rivera, T. Deegan, Y. Chen, M. Wightman, R. Toth, K. Labib, S. Mathea, N. Ranson, R. Fernandez-Busnadiego, M. Muqit

This study identifies TOM20, TOM70, TOM40, and associated subunits as critical for PINK1 activation in a reconstituted yeast system, providing insights for PINK1 activator development.

bioRxiv · Dec 23, 2023Biochemistry

DONSON is required for CMG helicase assembly in the mammalian cell cycle

K. Labib, C. Evrin, V. Alvarez, J. Ainsworth, R. Fujisawa, C. Alabert

This study identifies DONSON as essential for CDC45-MCM-GINS helicase assembly during S-phase, linking it to Meier-Gorlin Syndrome.

bioRxiv · Aug 16, 2023Biochemistry

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of nsp5 Main Protease

C. Basier, R. Beale, G. Bineva-Todd, B. Canal, J. F. Curran, T. D. Deegan, J. F. Diffley, R. Fujisawa, M. Howell, D. Joshi, K. Labib, C. T. Lim, J. Milligan, H. Nagaraj, N. O'Reilly, , T. U. Zeisner

This study identifies small molecule inhibitors of SARS-CoV-2 nsp5 main protease, finding calpain inhibitor I and peptidyl fluoromethylketones with potent antiviral activity.

bioRxiv · Apr 7, 2021Biochemistry

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp14/nsp10 Exoribonuclease

C. Basier, S. Basu, R. Beale, A. P. Bertolin, B. Canal, J. F. Curran, T. D. Deegan, J. F. Diffley, L. S. Drury, R. Fujisawa, M. Howell, K. Labib, A. W. McClure, J. Milligan, E. Roberts, , J. Zeng

This study identifies patulin and aurintricarboxylic acid as inhibitors of SARS-CoV-2 nsp14 exoribonuclease, showing antiviral activity in cell culture.

bioRxiv · Apr 7, 2021Biochemistry

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp3 Papain-like Protease

L. A. Armstrong, R. Beale, G. Bineva-Todd, B. Canal, J. F. Diffley, L. S. Drury, M. Howell, Y. Kulathu, K. Labib, C. T. Lim, J. Milligan, N. O'Reilly, E. Ozono, K. W. Tan, R. Ulferts, , J. Zeng

This study identifies two small molecule inhibitors of SARS-CoV-2 Nsp3 PLpro that inhibit viral replication in cell culture.

bioRxiv · Apr 7, 2021Biochemistry

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp15 Endoribonuclease

R. Beale, A. P. Bertolin, B. Canal, T. D. Deegan, J. F. Diffley, L. S. Drury, R. Fujisawa, M. Howell, K. Labib, A. W. McClure, R. Ulferts, F. Weissmann, M. Wu, J. Zeng

This study screens for small molecule inhibitors of SARS-CoV-2 nsp15 endoribonuclease and identifies NSC95397 as an in vitro inhibitor, though its antiviral efficacy remains to be determined.

bioRxiv · Apr 7, 2021Biochemistry

Identification of SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase

C. Basier, S. Basu, R. Beale, B. Canal, V. H. Cowling, J. F. Curran, T. D. Deegan, J. F. Diffley, L. S. Drury, R. Fujisawa, M. Howell, K. Labib, C. T. Lim, T. Mak, A. W. McClure, , T. U. Zeisner

This study identifies four small molecule inhibitors of SARS-CoV-2 nsp14 RNA cap methyltransferase, with three showing synergy with remdesivir in antiviral assays.

bioRxiv · Apr 7, 2021Bioengineering

The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans

Y. HONG, M. Velkova, N. Silva, M. Jagut, V. Scheidt, K. Labib, V. Jantsch, A. Gartner

This study identifies LEM-3/Ankle1 as a nuclease involved in processing meiotic recombination intermediates, promoting non-crossover (NCO) outcomes and resolving erroneous intermediates during meiotic divisions in C. elegans.

bioRxiv · Nov 21, 2017Cell Biology

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during cytokinesis

Y. HONG, R. Sonneville, B. Wang, V. Scheidt, B. Meier, A. Woglar, S. Demetriou, K. Labib, V. Jantsch, A. Gartner

This study identifies LEM-3 as a DNA nuclease that resolves chromatin bridges during cytokinesis in C. elegans embryos, highlighting its role in genome integrity.

bioRxiv · Nov 17, 2017Cell Biology