Mechanisms of Kinesin-1 activation by Ensconsin/MAP7 in vivo
M. Metivier, B. Monroy, E. Gallaud, R. Caous, A. Pascal, L. Richard-Parpaillon, A. Guichet, K. Ori-McKenney, R. Giet
This study identifies the Kinesin-1 activation mechanism by Ensconsin/MAP7, showing that the KBD domain binds and stimulates Kinesin-1 binding to Mts, with full-length Ensconsin enabling direct activation on microtubules.
bioRxiv · Jul 27, 2018Cell Biology