E. Gallaud

A force-sensitive mutation reveals a spindle assembly checkpoint-independent role for dynein in anaphase progression

This study identifies a mutation in dynein that causes mitotic spindle arrest independent of the spindle assembly checkpoint, revealing a load-dependent role in anaphase progression.

The spindle assembly checkpoint and the spatial activation of Polo kinase determine the duration of cell division and prevent neural stem cells tumor formation

This study shows that Polo kinase activity, regulated by Aurora A and B, controls cell division duration and prevents tumor formation in Drosophila neural stem cells by coupling mitotic progression with polarization.

Peripheral microtubules ensure asymmetric furrow positioning in neural stem cells

The paper shows that peripheral microtubules and the Chromosome Passenger Complex are required for cortical centralspindlin recruitment, which ensures asymmetric furrow positioning in neural stem cells.

Drosophila dTBCE recruits tubulin around chromatin to promote mitotic spindle assembly

The paper identifies dTBCE's role in promoting mitotic spindle assembly by recruiting tubulin around chromatin in Drosophila.

Dynamic centriolar relocalization of Polo kinase and Centrobin in early mitosis primes centrosomeasymmetry in fly neural stem cells

The paper shows Polo kinase and Centrobin relocalize from mother to daughter centrioles in fly neural stem cells during mitosis, establishing centrosome asymmetry that primes biased MTOC activity.

Mechanisms of Kinesin-1 activation by Ensconsin/MAP7 in vivo

This study identifies the Kinesin-1 activation mechanism by Ensconsin/MAP7, showing that the KBD domain binds and stimulates Kinesin-1 binding to Mts, with full-length Ensconsin enabling direct activation on microtubules.