Large-scale structural rearrangements unleash indiscriminate nuclease activity of CRISPR-Cas12a2
J. P. Bravo, T. Hallmark, B. Naegle, C. L. Beisel, R. N. Jackson, D. W. Taylor
The paper reports structures of Cas12a2 to elucidate its activation pathway and mechanism of indiscriminate nuclease activity against various substrates.
bioRxiv · Jun 13, 2022 · PreprintBiochemistry