Author

T. Hallmark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein structure prediction· 2 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

C. L. Beisel· 2 shared R. N. Jackson· 2 shared B. N. Gray· 1 shared B. Naegle· 1 shared D. J. Keiser· 1 shared D. W. Taylor· 1 shared E. Vialetto· 1 shared G. Neumann· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

C. L. Beisel

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Omics Scale Quantitative Mass Spectrometry Imaging of Lipids in Brain Tissue using a Multi-Class Internal Standard Mixture

M. Vandenbosch, S. M. Mutuku, M. J. Q. Mantas, N. H. Patterson, T. Hallmark, M. Claesen, R. M. A. Heeren, N. G. Hatcher, N. Verbeeck, K. Ekroos, S. R. Ellis

This paper introduces a method for quantitative mass spectrometry imaging of lipids in brain tissue using a multi-class internal standard mixture, revealing absolute lipid concentrations across multiple lipid classes.

bioRxiv · Jun 21, 2023Biochemistry

Cas12a2 elicits abortive infection via RNA-triggered destruction of double-stranded DNA

O. Dmytrenko, G. Neumann, T. Hallmark, D. J. Keiser, V. M. Crowley, E. Vialetto, I. Mougiakos, K. G. Wandera, H. Domgaard, J. Weber, J. Metcalf, M. B. Begemann, B. N. Gray, R. N. Jackson, C. L. Beisel

This study shows that Cas12a2 causes abortive infection by degrading double-stranded DNA through RNA-triggered activity, and demonstrates its use as an RNA detection tool.

bioRxiv · Jun 13, 2022 · PreprintMicrobiology

Large-scale structural rearrangements unleash indiscriminate nuclease activity of CRISPR-Cas12a2

J. P. Bravo, T. Hallmark, B. Naegle, C. L. Beisel, R. N. Jackson, D. W. Taylor

The paper reports structures of Cas12a2 to elucidate its activation pathway and mechanism of indiscriminate nuclease activity against various substrates.

bioRxiv · Jun 13, 2022 · PreprintBiochemistry