Author

C. L. Beisel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

K. G. Wandera· 2 shared R. N. Jackson· 2 shared T. Hallmark· 2 shared A. A. Jermusyk· 1 shared A. Cuenod· 1 shared A. Egli· 1 shared A. J. Westermann· 1 shared A. R. Hall· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

K. G. Wandera

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A CRISPR-based genetic screen in Bacteroides thetaiotaomicron reveals a small RNA modulator of bile susceptibility

G. Prezza, C. Liao, S. Reichardt, C. L. Beisel, A. J. Westermann

The paper uses CRISPRi in Bacteroides thetaiotaomicron to identify a small RNA that modulates bile salt susceptibility.

bioRxiv · Jul 3, 2023Microbiology

Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans

F. Benz, S. Camara-Wilpert, J. Russel, K. G. Wandera, R. Cepaite, M. Ares-Arroyo, J. V. Gomes-Filho, F. Englert, J. Kuehn, S. Gloor, A. Cuenod, M. Aguila-Sans, L. Maccario, A. Egli, L. Randau, , R. Pinilla-Redondo

This study shows type IV-A3 CRISPR-Cas systems use host adaptation machinery to update their CRISPR arrays and interfere with plasmid and phage transfer, supporting their role in plasmid competition.

bioRxiv · Jun 23, 2023 · PreprintMicrobiology

Cas12a2 elicits abortive infection via RNA-triggered destruction of double-stranded DNA

O. Dmytrenko, G. Neumann, T. Hallmark, D. J. Keiser, V. M. Crowley, E. Vialetto, I. Mougiakos, K. G. Wandera, H. Domgaard, J. Weber, J. Metcalf, M. B. Begemann, B. N. Gray, R. N. Jackson, C. L. Beisel

This study shows that Cas12a2 causes abortive infection by degrading double-stranded DNA through RNA-triggered activity, and demonstrates its use as an RNA detection tool.

bioRxiv · Jun 13, 2022 · PreprintMicrobiology

Large-scale structural rearrangements unleash indiscriminate nuclease activity of CRISPR-Cas12a2

J. P. Bravo, T. Hallmark, B. Naegle, C. L. Beisel, R. N. Jackson, D. W. Taylor

The paper reports structures of Cas12a2 to elucidate its activation pathway and mechanism of indiscriminate nuclease activity against various substrates.

bioRxiv · Jun 13, 2022 · PreprintBiochemistry

Tunable self-cleaving ribozymes for modulating gene expression in eukaryotic systems

T. Jacobsen, G. Yi, H. Al Asafen, A. A. Jermusyk, C. L. Beisel, G. T. Reeves

This study develops tunable self-cleaving ribozymes to modulate gene expression in eukaryotic systems, showing effectiveness in mammalian cells and Drosophila embryos.

bioRxiv · Sep 9, 2019Bioengineering