A Family of Glycosylated Macrolides Selectively Target Energetic Vulnerabilities in Leukemia
B. J. Reisman, H. Guo, H. E. Ramsey, M. T. Wright, B. I. Reinfeld, P. B. Ferrell, G. A. Sulikowski, W. K. Rathmell, M. R. Savona, L. Plate, J. L. Rubinstein, B. O. Bachmann
This study identifies the mitochondrial ATP synthase as the target of apoptolidin family glycomacrolides and demonstrates their efficacy in suppressing leukemia progression.
bioRxiv · May 31, 2021Biochemistry