ANTIMETABOLIC COOPERATIVITY WITH THE CLINICALLY APPROVED KIDROLASE AND TYROSINE KINASE INHIBITORS TO ERADICATE CML STEM CELLS
A. Trinh, R. Khamari, Q. Fovez, F.-X. Mahon, B. Turcq, D. Bouscary, P. Maboudou, M. Joncquel, V. Coiteux, N. Germain, W. Laine, S. Dekiouk, B. Ghesquiere, T. Idziorek, B. Quesnel, , P. Marchetti
This study shows that combining tyrosine kinase inhibitors with Kidrolase targets glutamine metabolism and enhances CML stem cell eradication.
bioRxiv · Sep 21, 2020 · PreprintCancer Biology