P. Marchetti

Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice

This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.

Proinflammatory Cytokines Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells

This study shows proinflammatory cytokines suppress NMD activity in β-cells by downregulating UPF3B, leading to increased alternative splicing and ECM-related gene expression, which contributes to β-cell dysfunction.

Interferon-α promotes neo-antigen formation andpreferential HLA-B-restricted antigen presentation in pancreatic β-cells

This study shows that IFN-α increases HLA-B-restricted antigen presentation in pancreatic β-cells, potentially influencing T1D pathogenesis.

Interferons are the key cytokines acting on pancreatic islets in type 1 diabetes

This study identifies IFN and IFNγ as key cytokines affecting pancreatic beta cells in type 1 diabetes through RNA-sequencing analysis and comparison with T1D islet signatures.

Direct optical nanoscopy unveils signatures of cytokine-induced β-cell structural and functional stress

The paper uses advanced microscopy to show proinflammatory cytokines reduce insulin granules and cause structural and functional stress in beta-cells.

Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity

This study identifies differential CpG methylation at the Nnat gene as a mechanism establishing beta cell heterogeneity during development and its potential role in diabetes.

The gene signatures of human alpha cells in types 1 and 2 diabetes indicate disease-specific pathways of alpha cell dysfunction

This study identifies distinct gene expression patterns in human alpha cells from type 1 and type 2 diabetes, revealing disease-specific pathways of dysfunction.

Increased expression of viral sensor MDA5 in pancreatic islets and in hormone-negative endocrine cells in recent onset type 1 diabetic donors

This study shows increased MDA5 expression in pancreatic islets and hormone-negative endocrine cells in recent-onset T1D donors compared to non-diabetic controls.

Reduced miR-184-3p expression occurring in Type 2 diabetic pancreatic islets protects β-cells from lipotoxic and proinflammatory apoptosis via a CRTC1-dependent mechanism

The paper shows reduced miR-184-3p in T2D pancreatic islets protects β-cells from apoptosis by upregulating CRTC1, with NKX6.1 controlling miR-184-3p expression.

ANTIMETABOLIC COOPERATIVITY WITH THE CLINICALLY APPROVED KIDROLASE AND TYROSINE KINASE INHIBITORS TO ERADICATE CML STEM CELLS

This study shows that combining tyrosine kinase inhibitors with Kidrolase targets glutamine metabolism and enhances CML stem cell eradication.

SARS-CoV-2 receptor Angiotensin I-Converting Enzyme type 2 (ACE2) is expressed in human pancreatic β-cells and in the human pancreas microvasculature

This study shows ACE2 is expressed in human pancreatic β-cells and microvasculature, suggesting a potential link between SARS-CoV-2 and diabetes through β-cell infection or microvasculature involvement.

Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell identity and function.

This study investigates the role of Pax6os1/PAX6-AS1 in beta cell identity and function, finding that its upregulation in diabetes contributes to impaired functionality and that targeting it may improve glucose homeostasis.

Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activity

This study shows that sorcin enhances ATF6 transcriptional activity, which is reduced during lipotoxic stress and contributes to beta cell failure in type 2 diabetes.

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a new regulator of insulin secretion

The paper identifies FCHSD2 as a new regulator of insulin secretion by analyzing 3D chromatin interactions at the STARD10 locus in human islets.