Divergent and dominant anti-inflammatory effects of patient-derived anti-citrullinated protein antibodies (ACPA) in arthritis development
B. Raposo, M. G. Afonso, L. Israelsson, H. Wähämaa, R. Stalesen, F. Wermeling, A. Hensvold, C. Grönwall, B. Rethi, L. Klareskog, V. Malmström
This study shows that most patient-derived anti-citrullinated protein antibodies (ACPA) are anti-inflammatory, with some clones inhibiting arthritis while others promote disease, highlighting the complexity of ACPA's role in rheumatoid arthritis.
bioRxiv · Sep 30, 2022 · PreprintImmunology