F. Wermeling

Dnmt3a mutations limit normal and autoreactive Tfh differentiation

This study shows that Dnmt3a mutations impair Tfh differentiation, contributing to autoimmune joint inflammation and reduced immune responses.

MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia

This study shows that MDM2 inhibitors nutlin-3a and navtemadelin remain effective in hypoxic conditions in human and mouse cancer cells with wild-type p53, but not in mutant or null p53 cells.

Divergent and dominant anti-inflammatory effects of patient-derived anti-citrullinated protein antibodies (ACPA) in arthritis development

This study shows that most patient-derived anti-citrullinated protein antibodies (ACPA) are anti-inflammatory, with some clones inhibiting arthritis while others promote disease, highlighting the complexity of ACPA's role in rheumatoid arthritis.

CRISPR enriches for cells with mutations in a p53-related interactome, and this can be inhibited.

The paper shows that CRISPR enriches cells with p53-related mutations and demonstrates that transient p53 inhibition can suppress this effect.

A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system

This paper introduces a CRISPR-based assay to identify drug targets affecting hematopoietic cells by analyzing genotype enrichment in mixed CRISPR populations.

Identifying novel B-cell targets for chronic inflammatory autoimmune disease by screening of chemical probes in a patient-derived cell assay

The paper screens chemical probes in a patient-derived cell assay to identify novel B-cell targets for chronic inflammatory autoimmune diseases, finding inhibitors of bromodomain proteins and histone methyl transferases effective in blocking B-cell function.