Insight into mammary gland development and tumor prevention in a newly developed metastatic mouse model of breast cancer
B. To, C. Broeker, J.-R. Jhan, R. Rempel, J. P. Rennhack, D. Hollern, L. Jackson, D. Judah, M. Swiatnicki, E. Bylett, R. Kubiak, J. Honeysett, S. Reaz, J. R. Nevins, E. R. Andrechek
This study investigates the role of E2F5 in mammary gland development and tumor prevention using a mouse model, finding that its loss leads to dysregulated Cyclin D1 and metastatic breast tumors.
bioRxiv · Sep 24, 2021 · PreprintCancer Biology