Author

J. P. Rennhack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Organism:mouse· 2

Frequent Co-Authors

E. R. Andrechek· 3 shared D. Hollern· 2 shared M. R. Swiatnicki· 2 shared R. Kubiak· 2 shared W. Hahn· 2 shared A. McAuliff· 1 shared A. T. Cheung· 1 shared A. V. Perry· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

E. R. Andrechek

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5 papers

Recent·Most cited

Aberrant cell state plasticity mediated by developmental reprogramming precedescolorectal cancer initiation

P. Bala, J. P. Rennhack, D. Aitymbayev, C. X. Morris, S. M. Moyer, G. N. Duronio, P. Doan, z. Li, X. Liang, J. L. Hornick, M. B. Yurgelun, W. Hahn, N. S. Sethi

The paper shows that aberrant cell state plasticity, driven by regenerative activity and developmental reprogramming, occurs before colorectal cancer initiation in mouse models and human patients.

bioRxiv · Sep 22, 2022Cancer Biology

Insight into mammary gland development and tumor prevention in a newly developed metastatic mouse model of breast cancer

B. To, C. Broeker, J.-R. Jhan, R. Rempel, J. P. Rennhack, D. Hollern, L. Jackson, D. Judah, M. Swiatnicki, E. Bylett, R. Kubiak, J. Honeysett, S. Reaz, J. R. Nevins, E. R. Andrechek

This study investigates the role of E2F5 in mammary gland development and tumor prevention using a mouse model, finding that its loss leads to dysregulated Cyclin D1 and metastatic breast tumors.

bioRxiv · Sep 24, 2021 · PreprintCancer Biology

Elevated phosphorylation of EGFR in NSCLC due to mutations in PTPRH

M. R. Swiatnicki, J. P. Rennhack, D. Hollern, A. V. Perry, R. Kubiak, S. M. Riveria Riveria, S. O'Reilly, E. R. Andrechek

This paper shows that PTPRH mutations in NSCLC lead to elevated EGFR phosphorylation, which can be targeted by existing EGFR inhibitors.

bioRxiv · Sep 14, 2021Cancer Biology

CREB5 reprograms nuclear interactions to promote resistance to androgen receptor targeting therapies

J. H. Hwang, R. Arafeh, J.-H. Seo, S. C. Baca, M. Ludwig, T. E. Arnoff, C. Richter, H. E. Bergom, S. McSweeney, J. P. Rennhack, S. A. Klingenberg, A. T. Cheung, J. Kwon, J. So, S. Kregel, , W. Hahn

This study identifies CREB5 as a key driver of resistance to androgen receptor targeting therapies by reprogramming nuclear interactions and activating TGFβ and Wnt signaling pathways.

bioRxiv · Aug 18, 2021Cancer Biology

E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration

D. P. Hollern, M. R. Swiatnicki, J. P. Rennhack, S. A. Misek, B. C. Matson, A. McAuliff, K. A. Gallo, K. M. Caron, E. R. Andrechek

This study identifies E2F1 as a master regulator of metastasis by upregulating Fgf13, which promotes breast cancer cell migration and pulmonary metastasis.

bioRxiv · Jun 13, 2019Cancer Biology