L. Jackson

Female cichlids attack and avoid-but will still mate with-androgen receptor mutant males that lack male-typical body coloration

The paper investigates female cichlid mating behaviors by testing AR mutant males lacking coloration, finding aggression but mating occurs regardless of coloration.

Diet Induced Obesity and Diabetes Enhance Mortality and Reduces Vaccine Efficacy for SARS-CoV-2

This study shows that obesity and diabetes increase SARS-CoV-2 mortality and reduce vaccine efficacy in mice, with neutrophil depletion improving outcomes.

Stimulation of phospholipase Cβ1 by Gαq promotes the assembly of stress granule proteins

This study shows that Gαq activation promotes stress granule formation via cytosolic PLCβ1, leading to the assembly of stress granule proteins.

Insight into mammary gland development and tumor prevention in a newly developed metastatic mouse model of breast cancer

This study investigates the role of E2F5 in mammary gland development and tumor prevention using a mouse model, finding that its loss leads to dysregulated Cyclin D1 and metastatic breast tumors.

SARS-CoV-2 cell-to-cell spread occurs rapidly and is insensitive to antibody neutralization

This study shows SARS-CoV-2 spreads rapidly between cells via fusion and is resistant to antibody neutralization, unlike cell-free virus.

Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants

This study assesses the durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants over seven months, finding persistent but reduced binding and functional responses.

HIV cell-to-cell spread slows evolution of drug resistance

This study shows that HIV cell-free infection accelerates the evolution of drug resistance compared to cell-to-cell spread, with cell-free infection enabling multidrug resistance in the presence of two reverse transcriptase inhibitors.

Complementation can maintain a quasispecies of drug sensitive and resistant HIV

The paper shows that complementation between drug-sensitive and resistant HIV genotypes maintains a stable quasispecies, preventing the resistant genotype from outcompeting the sensitive one.

Simulation of the Gαq /Phospholipase Cβ1 Signaling Pathway Returns Differentiated PC12 Cells to a Stem-like State

The paper shows that reducing PLCβ1 or activating Gq to move PLCβ1 to the plasma membrane reverts differentiated PC12 cells to a stem-like state, characterized by morphology changes, proliferation, and expression of stem cell factors.

Hemozoin produced by mammals confers heme tolerance

The paper shows that mice lacking HRG1 accumulate excess heme in macrophages, which they tolerate by forming hemozoin, a process previously only observed in blood-feeding parasites.