Structural adaptation of oxygen tolerance in 4-hydroxybutyrl-CoA dehydratase, a key enzyme of archaeal carbon fixation
H. DeMirci, B. Tolar, T. Doukov, A. Petriceks, A. Pal, Y. Yoshikuni, A. Gomez, D. A. Saez, E. Vohringer-Martinez, T. Schwander, T. J. Erb, C. A. Francis, S. Wakatsuki
The paper investigates how 4HBD, a key enzyme in archaeal carbon fixation, adapted structurally to become oxygen-tolerant, revealing evolutionary changes that enabled aerobic metabolism.
bioRxiv · Feb 5, 2020 · PreprintEvolutionary Biology