Author

B. Townsend

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:proteomics· 1

Frequent Co-Authors

B. M. Collins· 2 shared M. Lazarou· 2 shared M. Pagano· 2 shared P. Kulkarni· 2 shared S. S. Ooi· 2 shared A. Marzio· 1 shared D. C. Ng· 1 shared D. Eldershaw· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

B. M. Collins

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2 papers

Recent·Most cited

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

G. T. Nguyen-Dien, B. Townsend, P. Kulkarni, K.-L. Kozul, S. S. Ooi, D. Eldershaw, S. Weeratunga, M. Liu, M. J. Jones, S. S. Millard, D. C. Ng, M. Pagano, D. Komander, M. Lazarou, B. M. Collins, J. K. Pagan

This study identifies PPTC7 as a cofactor for SCFFBXL4-mediated degradation of BNIP3 and NIX, suppressing mitophagy and revealing a feedback mechanism to regulate mitochondrial homeostasis.

bioRxiv · Feb 23, 2024Cell Biology

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

J. Pagan, G. Nguyen-Dien, K. Kozul, Y. Cui, B. Townsend, S. S. Ooi, M. Pagano, M. Lazarou, R. Taylor, B. M. Collins, R. G. Parton, P. Kulkarni, N. Carrodus, S. Zuryn, S. Millard, , M. Jones

This study identifies FBXL4 as a suppressor of basal mitophagy by ubiquitylating and degrading NIX and BNIP3, and shows pathogenic variants disrupt this function leading to mtDNA depletion syndrome.

bioRxiv · Oct 12, 2022Cell Biology