Cell BiologybioRxiv
FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors
J. Pagan, G. Nguyen-Dien, K. Kozul…·M. Jones
This study identifies FBXL4 as a suppressor of basal mitophagy by ubiquitylating and degrading NIX and BNIP3, and shows pathogenic variants disrupt this function leading to mtDNA depletion syndrome.
DOI 10.15252/embj.2022112767