Y. Cui

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

The paper investigates gene loss in Vibrio parahaemolyticus pandemic clones, showing it drives wave succession through environmental and transmission advantages.

Single-molecule analysis reveals the phosphorylation of FLS2 governs its spatiotemporal dynamics and immunity

This study shows phosphorylation of FLS2 at Ser-938 affects its dynamics and immune response by directing it to AtRem1.3 nanodomains.

Hepatic lipopolysaccharide binding protein partially uncouples inflammation from fibrosis in MAFLD

This study shows that reducing hepatic LBP in mice limits inflammation but not fibrosis in MAFLD, suggesting inflammation may not be a primary driver of fibrosis.

A safe insect-based Chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques

This study evaluates an insect-based chimeric virus vaccine against Chikungunya fever, showing rapid and durable protection in macaques.

Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK

This study identifies PLCβ4 as a key regulator of RANKL-induced osteoclastogenesis by interacting with MKK3 and p38 MAPK, showing its potential as a therapeutic target for bone diseases.

Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination

This study identifies potent and broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from a vaccinated donor, showing their efficacy against multiple variants and providing insights for therapeutic development.

A conserved Pol II elongator SPT6L mediates Pol V transcription elongation to regulate RNA-directed DNA methylation in Arabidopsis

Target-aware Molecule Generation for Drug Design Using a Chemical Language Model

This paper introduces TamGen, a chemical language model for target-aware molecule generation, and shows it produces high-quality compounds with inhibitory activity against Tuberculosis ClpP protease.

Dual carbon sequestration with photosynthetic living materials

This paper develops photosynthetic living materials that sequester CO2 through dual mechanisms, achieving 2.5 mg CO2 per gram of material over 30 days.

Variability in single-cell oxygen consumption kinetics

This study measures oxygen consumption kinetics in single human hepatic cells and finds size-dependent metabolic rates and cooperative behavior in cell clusters.

Acquisition of Auditory Discrimination Mediated by Different Processes through Two Distinct Circuits Linked to the Lateral Striatum

This study shows that different striatal subregions, aDLS and pVLS, use distinct processes to mediate auditory discrimination learning in rats.

Enhanced neutralization of SARS-CoV-2 XBB sub-lineages and BA.2.86 by a tetravalent COVID-19 vaccine booster

This study evaluates the neutralization efficacy of a tetravalent vaccine booster against emerging SARS-CoV-2 variants, finding it induces higher neutralizing titers than breakthrough infection.

Defense mechanism of a bacterial retron supramolecular assembly

The paper identifies a phage-encoded DNA methyltransferase as a trigger for the Ec86 retron system and describes its supramolecular assembly and defense mechanism.

NUCLEOPORIN1 mediates proteasome-based degradation of ABI5 to regulate Arabidopsis seed germination

This study identifies NUP1's role in Arabidopsis seed germination by mediating proteasome-dependent degradation of ABI5.

Metabolomic changes associated with acquired resistance to Ixodes scapularis

This study identifies metabolomic changes in guinea pigs with acquired resistance to Ixodes scapularis ticks, showing that tyrosine pathway components like HPLA contribute to resistance.

Competitive fitness and homologous recombination of SARS-CoV-2 variants of concern

This study examines the competitive fitness and homologous recombination of SARS-CoV-2 variants in vitro, showing cell-specific fitness differences and recombination hotspots.

SWI/SNF chromatin remodeling determines brassinosteroid-induced transcriptional activation

This study shows that SWI/SNF chromatin remodeling is required for BZR1-mediated transcriptional activation in Arabidopsis thaliana.

Select EZH2 inhibitors enhance the viral mimicry effects of DNMT inhibition through a mechanism involving calcium-calcineurin-NFAT signaling

The paper shows that combining DNMT inhibitors with selective EZH2 inhibitors enhances antiproliferative effects in colon cancer by modulating calcium-calcineurin-NFAT signaling and viral mimicry.

Tumor-specific neutrophils originating from meninges promote glioblastoma

This study identifies tumor-specific neutrophils in glioblastoma that originate from meninges and contribute to immunosuppression, showing their role in tumor progression and poor prognosis.

Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells

This study shows that vaccinating with mycobacterial lipid-loaded nanoparticles induces persistent lipid antigen presence and memory T cell differentiation in mice.

Neutralization of SARS-CoV-2 BQ.1.1 and XBB.1.5 by Breakthrough Infection Sera from Previous and Current Waves in China

This study assesses neutralization of SARS-CoV-2 Omicron subvariants by sera from different vaccination and breakthrough infection cohorts, finding that BQ.1.1 and XBB.1.5 show strong neutralization evasion.

Three-dimensional morphological analysis revealed the cell patterning bases for the sexual dimorphism development in the liverwort Marchantia polymorpha

The paper uses 3D morphological analysis to show how germline precursor distribution differs between male and female liverworts, driven by MpFGMYB, shaping sexual dimorphism in M. polymorpha.

Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China

The paper uses metagenomics to identify 22 RNA viruses in ticks from northeastern China, revealing novel species and highlighting public health risks from emerging tick-borne viruses.

Organization, genomic targeting and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis

DNA-caged Nanoparticles via Electrostatic Self-Assembly

This paper introduces an electrostatic DNA caging method for nanoparticle modification, demonstrating its versatility in biosensing and material applications.

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

This study identifies FBXL4 as a suppressor of basal mitophagy by ubiquitylating and degrading NIX and BNIP3, and shows pathogenic variants disrupt this function leading to mtDNA depletion syndrome.

Genetic, Clinical Underpinnings of Brain Change Along Two Neuroanatomical Dimensions of Clinically-defined Alzheimer's Disease

This study identifies two brain atrophy dimensions in Alzheimer's disease using Surreal-GAN and links them to genetic and clinical factors, revealing distinct pathological mechanisms.

Endogenous Plasmids and Reductive Genome Evolution in Host-Associated Bacteria

This study investigates reductive genome evolution in Cardinium endosymbionts, identifying endogenous plasmids and their enzymes as drivers of genome reduction.

Neutralization of Omicron BA.4/BA.5 and BA.2.75 by Booster Vaccination or BA.2 Breakthrough Infection Sera

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

A Multifunctional Anchor for Multimodal Expansion Microscopy

This paper introduces a multifunctional anchor for expansion microscopy, enabling simultaneous imaging of multiple biomolecules with reduced cost and complexity.