Author

J. Pagan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. D. Attie· 1 shared A. Gaca· 1 shared A. Marzio· 1 shared B. M. Collins· 1 shared B. Townsend· 1 shared C. Balnis· 1 shared D. J. Pagliarini· 1 shared E. H. Rashan· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiochemistry

A. D. Attie

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

N. M. Niemi, L. R. Serrano, L. K. Muehlbauer, C. Balnis, K.-L. Kozul, E. H. Rashan, E. Shishkova, K. L. Schueler, M. P. Keller, A. D. Attie, J. Pagan, J. J. Coon, D. J. Pagliarini

This study shows that Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy, leading to metabolic defects and early lethality in mice.

bioRxiv · Feb 28, 2023Biochemistry

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

J. Pagan, G. Nguyen-Dien, K. Kozul, Y. Cui, B. Townsend, S. S. Ooi, M. Pagano, M. Lazarou, R. Taylor, B. M. Collins, R. G. Parton, P. Kulkarni, N. Carrodus, S. Zuryn, S. Millard, , M. Jones

This study identifies FBXL4 as a suppressor of basal mitophagy by ubiquitylating and degrading NIX and BNIP3, and shows pathogenic variants disrupt this function leading to mtDNA depletion syndrome.

bioRxiv · Oct 12, 2022Cell Biology

Functional modulation of T follicular cells in vivo enhances antigen-specific humoral immunity

J. Pagan, H. Vlakamis, A. Gaca, R. Xavier, R. Anthony

The paper shows that reducing TFR influence through antibiotic treatment or PD-1 blockade enhances antigen-specific IgG affinity and TFH cell numbers in mice.

bioRxiv · Nov 17, 2020Immunology