Functional plasticity and reversible growth behavior of patients acute myeloid leukemia stem cells growing in mice
S. Ebinger, C. Zeller, M. Carlet, D. Senft, W.-H. Liu, M. Rothenberg-Thurley, K. H. Metzeler, K. Spiekermann, B. Vick, I. Jeremias
This study shows AML stem cells can switch between low-cycling, treatment-resistant and actively proliferating states in mice, suggesting functional plasticity that could be targeted therapeutically.
bioRxiv · Jul 19, 2019 · PreprintCancer Biology