TMEM165 replenishes lysosomal calcium stores, protects cells against calcium overload, and mediates calcium-induced lysosomal H+ leakage
R. Chan, B. Liu, D. Jaslan, L. Kujec, V. Kurdina, B. Warnke, Y. Klingl, A. Petrauskas, K. Maeda, P. D. D. C. M. Grimm, M. Jaattela
This study identifies TMEM165 as a lysosomal calcium importer that prevents calcium overload and regulates lysosomal pH.
bioRxiv · May 9, 2024 · PreprintCell Biology