R. Chan

TMEM165 replenishes lysosomal calcium stores, protects cells against calcium overload, and mediates calcium-induced lysosomal H+ leakage

This study identifies TMEM165 as a lysosomal calcium importer that prevents calcium overload and regulates lysosomal pH.

TL1A/DR3 signaling regulates the generation of pathogenic Th9 cells in experimental inflammatory bowel disease

This study shows that DR3 signaling promotes Th9 cell pathogenicity in CD-like ileitis by enhancing pro-inflammatory signatures and reducing anti-inflammatory responses.

Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome

The paper investigates how strain dropouts in the gut microbiome affect community metabolism and host physiology, finding that functionally redundant strains can have significant impacts outside their niche.

PanIN and CAF Transitions in Pancreatic Carcinogenesis Revealed with Spatial Data Integration

This paper develops a new protocol for spatial transcriptomics analysis of FFPE PanIN specimens and integrates it with imaging and scRNA-seq to study the progression from PanIN to PDAC.

γδ-Thymocyte Maturation and Emigration

This study shows that adult mice have two distinct streams of γδ-T cells: one maturing in the periphery and another completing maturation in the thymus, with a fetal-derived resident population.

Quantitative study of unsaturated transport of glycerol through aquaglyceroporin that has high affinity for glycerol

This study combines in silico and in vitro experiments to show that AQP3 facilitates unsaturated glycerol transport through concerted movement of two glycerol molecules despite high substrate affinity.

In silico simulations of erythrocyte aquaporins with quantitative in vitro validation

This study compares TIP3P and TIP4P water models in simulating erythrocyte aquaporins using molecular dynamics and experimental validation.