K. Maeda

A system-wide analysis of lipid transfer proteins delineates lipid mobility in human cells

The paper identifies lipid cargoes for half of analyzed human LTPs, revealing selectivity for lipid head groups and acyl chains and new lipid-organelle relationships.

TMEM165 replenishes lysosomal calcium stores, protects cells against calcium overload, and mediates calcium-induced lysosomal H+ leakage

This study identifies TMEM165 as a lysosomal calcium importer that prevents calcium overload and regulates lysosomal pH.

Adaptive evolution of sesquiterpene deoxyphomenone in mycoparasitism by Hansfordia pulvinata associated with horizontal gene transfer from Aspergillus species

This study identifies deoxyphomenone biosynthesis gene clusters in Hansfordia pulvinata and related Aspergillus species, showing horizontal gene transfer and adaptive evolution in mycoparasitism.

Discovery of Novel Replication Proteins for Large Plasmids in Cyanobacteria and Their Potential Applications in Genetic Engineering

This study identifies two novel replication proteins, CyRepX1 and CyRepX2, from a cyanobacterial plasmid and demonstrates their compatibility with existing replication systems, suggesting potential applications in genetic engineering.

Lipid levels correlate with neuronal and dopaminergic markers during the differentiation of SH-SY5Y cells

This study characterizes lipidome changes during SH-SY5Y cell differentiation into dopaminergic neurons and links lipid levels to neuronal and dopaminergic markers.

Sequential breakdown of the complex Cf-9 leaf mould resistance locus in tomato by Fulvia fulva

This study identifies Avr9B, an effector that allows F. fulva to overcome Cf-9B resistance in tomato, showing sequential breakdown of the Cf-9 locus.

Structural polymorphism of the nucleic acids in pentanucleotide repeats associated with CANVAS

The paper investigates the structural polymorphism of RFC1 pentanucleotide repeats associated with CANVAS, showing different G-quadruplex and hairpin structures in DNA and RNA.

HIV-Tocky system to visualize proviral expression dynamics

The paper introduces HIV-Tocky, a reporter system using a fluorescent Timer protein to visualize HIV-1 provirus expression dynamics and identifies two latent subsets of proviruses.

Identification of inosine monophosphate dehydrogenase as a potential target for anti-monkeypox virus agents

This study identifies IMPDH as a potential target for anti-monkeypox virus agents by showing that compounds targeting this enzyme inhibit MPXV replication more effectively than existing treatments.

Morphogenesis of bullet-shaped rabies virus particles requires a functional interplay between the viral matrix protein and ESCRT-I component TSG101

This study identifies the interaction between rabies virus matrix protein and TSG101 as essential for bullet-shaped virion formation and efficient budding.

Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells

This study shows that excess mannose causes dNTP depletion, leading to genomic instability and enhanced sensitivity to chemotherapy in cancer cells.

Lysosome repair by ER-mediated cholesterol transfer

The paper identifies an ER-mediated cholesterol transfer mechanism for lysosome repair independent of ESCRTs, involving PI4K2A and OSBP.

Impact of reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters

This study investigates reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters, finding that immunity prevents pneumonia but allows viral replication in the upper airways with increased mutation diversity.

Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates

This study evaluates the replicative ability and pathogenicity of SARS-CoV-2 BA.2.75 isolates in Syrian hamsters, finding higher lung replication and focal pneumonia compared to BA.2 and BA.5.

Circadian ribosome profiling reveals a role for the Period2 upstream open reading frame in sleep

This study uses ribosome profiling to show that uORFs in Per2 mRNA regulate translation and sleep in mice.

Potential anti-monkeypox virus activity of atovaquone, mefloquine, and molnupiravir, and their potential use as treatments

This study identifies atovaquone, mefloquine, and molnupiravir as potential anti-monkeypox virus drugs, with atovaquone showing enhanced efficacy when combined with tecovirimat.

SARS-CoV-2-neutralizing humoral IgA response occurs earlier but modest and diminishes faster compared to IgG response.

This study compares the neutralizing activity of IgA and IgG antibodies against SARS-CoV-2 in COVID-19 patients and vaccine recipients, finding that IgA response is modest, peaks earlier, and declines faster than IgG.

Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway

The paper shows pathogenic SMS2 variants disrupt lipid landscapes in the secretory pathway by trapping sphingomyelin in the ER and altering cholesterol and glycerophospholipid distributions.

Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2

The paper compares the efficacy of neutralizing antibodies and antiviral drugs against SARS-CoV-2 Omicron subvariants BA.1 and BA.2, finding differential responses to specific treatments.

A widely-distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro

The paper develops a new assay to evaluate latency-reversing agents by eliminating HIV-1 proviruses in a long-term cell culture system.

Cellular toxicity of iHAP1 and DT-061 does not occur through PP2A-B56 targeting

This study challenges previous claims that iHAP1 and DT-061 target PP2A-B56 complexes, showing instead that they exert toxicity through microtubule disruption and ER/Golgi disruption, respectively.

Highly-Neutralizing COVID-19-Convalescent-Plasmas Potently Block SARS-CoV-2 Replication and Pneumonia in Syrian Hamsters.

This study shows that highly-neutralizing COVID-19 convalescent plasmas significantly reduce SARS-CoV-2 viral titers and lung lesions in Syrian hamsters compared to moderately neutralizing plasmas.

Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells in cynomolgus macaques

This study shows that subacute SARS-CoV-2 replication can be controlled without CD8+ T cells in cynomolgus macaques, suggesting CD8+ T-cell dysfunction may not solely cause viral control failure.

Biosynthesis system of Synechan, a sulfated exopolysaccharide, in the model cyanobacterium Synechocystis sp. PCC 6803

The paper identifies genes involved in synechan biosynthesis in Synechocystis sp. PCC 6803 and suggests a model for its synthesis apparatus.

Development of a reverse transcription polymerase chain reaction for the detection of severe fever with thrombocytopenia syndrome virus from suspected infected animals

This paper develops an RT-PCR assay to detect SFTSV in suspected animals, identifying 5 positive cases among 56 samples and demonstrating its sensitivity and specificity.