B. Liu

Nucleoid-associated proteins sense phage-induced genome damage to elicit abortive infection

This study identifies a novel bacterial defense mechanism where nucleoid-associated proteins detect phage-induced genome damage by relocating to the cytoplasm and activating immune effectors.

Genetic variation in the species Arabidopsis thaliana reveals the existence of natural heat resilience factors for meiosis

This study identifies natural heat resilience factors in Arabidopsis thaliana that enhance meiotic stability under heat stress, with implications for crop breeding.

CREEPING STEM1 Regulates Directional Auxin Transport for Lodging Resistance in Soybean

This study identifies the CS1 gene in soybean, which regulates directional auxin transport and enhances lodging resistance, improving yield under high planting density.

Lipid droplets restrict phagosome formation during Candida challenge

This study shows that lipid droplets restrict phagosome formation in macrophages during Candida infection, protecting cells from death and offering a potential drug target.

Defining cellular determinants of resistance to PD-1 pathway blockade in non-small-cell lung cancer

This study identifies MMP1+ fibroblasts as a cellular determinant of resistance to PD-1 pathway blockade in NSCLC by analyzing single-cell RNA sequencing data and spatial architecture.

Post-flowering photoperiod sensitivity of soybean in pod-setting responses

This study shows that soybean pod formation is sensitive to photoperiod, with LD conditions delaying pod formation and SD conditions affecting pistil morphology to influence pod-setting timing.

Multi-omics reveals AKR1B1-regulated galactose metabolic as a driver of gastrointestinal stromal tumor progression

This study identifies AKR1B1-regulated galactose metabolism as a driver of gastrointestinal stromal tumor progression through multi-omics analysis.

Quantitative and systematic NMR measurements of sequence-dependent A-T Hoogsteen dynamics uncovers unique conformational specificity in the DNA double helix

This study measures sequence-dependent A-T Hoogsteen dynamics in DNA using NMR, revealing distinct conformational specificity and sequence dependence.

TMEM165 replenishes lysosomal calcium stores, protects cells against calcium overload, and mediates calcium-induced lysosomal H+ leakage

This study identifies TMEM165 as a lysosomal calcium importer that prevents calcium overload and regulates lysosomal pH.

MIPDB: A maize image-phenotype database with multi-angle and multi-time characteristics

The paper introduces MIPDB, a maize image-phenotype database with multi-angle and multi-time images, providing a high-quality dataset for deep learning-based phenomics research.

Tobacco Smoke Exposure is Characterized by a Distinct Nasal Rhinotype in a Pediatric Population

The paper examines the impact of secondhand tobacco smoke exposure on the nasal microbiome in children, finding a distinct microbial rhinotype associated with higher cotinine levels.

Phenylphenalenones and Linear Diarylheptanoid Derivatives are Biosynthesized via Parallel Routes in Musella lasiocarpa, the Chinese Dwarf Banana

The paper identifies biosynthetic genes and pathways for phenylphenalenones and linear diarylheptanoid derivatives in Musella lasiocarpa using transcriptomics and biochemical assays.

Effect of Electroacupuncture Pretreatment on Cognitive Impairment and Mitophagy in Aging Model Rats and its mechanism

This study investigates how electroacupuncture pretreatment affects cognitive impairment and mitophagy in aging rats, finding it improves cognitive function by enhancing mitophagy and mitochondrial function.

Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2

This study identifies SIRT2 as a regulator of β-cell proliferation, showing its role in controlling β-cell expansion during hyperglycemia while preserving feedback mechanisms.

The impact of Bacillus coagulans X3 on available nitrogen content, bacterial community composition, and nitrogen functional gene levels when composting cattle manure

This study examines how adding Bacillus coagulans X3 to cattle manure compost affects nitrogen levels, bacterial communities, and nitrogen-related genes.

General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension through HIF-2α/Notch4 Pathway

Ultraviolet attenuates centromere-mediated meiotic genome stability and alters gametophytic ploidy consistency in flowering plants

This study shows UV radiation reduces crossover rates and disrupts meiotic spindle organization in Arabidopsis, leading to unreduced gametes and altered genome stability.

Transcriptomic and epigenetic responses shed light on soybean resistance to Phytophthora sansomeana

This study examines transcriptomic and epigenetic responses in soybean lines resistant and susceptible to Phytophthora sansomeana, identifying key genes and regulatory mechanisms involved in defense.

Mouse Adaptation of Human Inflammatory Bowel Diseases Microbiota Enhances Colonization Efficiency and Alters Microbiome Aggressiveness Depending on Recipient Colonic Inflammatory Environment

This study shows that adapting human IBD microbiota for mice improves colonization efficiency and alters microbiome aggressiveness based on the recipient's inflammatory environment.

Recognition and localization of maize leaves in RGB images based on Point-Line Net

This paper develops Point-Line Net, a deep learning method for detecting maize leaves and roots in field images, achieving 81.5% object detection accuracy and 33.5% keypoint detection performance.

Loss-of-function mutation in the polyamine transporter gene OsLAT5 as a selectable marker for genome editing

The paper demonstrates that loss-of-function mutations in OsLAT5 confer resistance to methylviologen, providing a selectable marker for genome editing in rice.

A Day in the Life of Arabidopsis: 24-Hour Time-lapse Single-nucleus Transcriptomics Reveal Cell-type specific Circadian Rhythms

This study uses snRNA-seq to analyze circadian rhythms in Arabidopsis over 24 hours, revealing cell-type specific gene expression patterns and identifying key circadian regulators.

A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and S. aureus contaminated bone implants in a mouse femur model

This paper develops a semi-automated cell tracking protocol to quantify neutrophil swarming in a mouse femur model with and without S. aureus infection, showing increased speed, displacement, and directionality in infected mice.

High-fidelity, generalizable light-field reconstruction of biological dynamics with physics-informed meta neural representation

This paper introduces LFMNR, a method for high-fidelity 3D reconstruction of biological dynamics using physics-informed neural representations and meta-learning, achieving improved resolution and speed.

USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase transition potential

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

WTAP, transcriptionally regulated by p65, promotes inflammation through m6A modification and phase separation

This study identifies WTAP as a p65-regulated m6A writer that promotes inflammation via phase separation and m6A modification, offering a therapeutic target for hyperinflammation.

Dense Sampling of Taxa and Genomes Untangles the Phylogenetic Backbone of a Non-model Plant Lineage Rife with Deep Hybridization and Allopolyploidy

The paper constructs a robust phylogenetic backbone for the Campanuleae tribe using genomic data and phylogenetic methods, revealing hybridization and allopolyploidy as key drivers of diversification.

Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein driving the genesis of Omicron variants

The paper identifies public antibodies using VL6-57 light chains that target a conserved epitope on SARS-CoV-2 spike protein, showing how Omicron variants evolved to escape these antibodies.

NanoNERF: A nanoscale NERF blaster replica made of DNA

The paper describes the design and creation of NanoNERF, a nanoscale DNA origami replica of a NERF blaster, and discusses its potential applications.

Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

The paper identifies sphingolipids as regulators of synphilin-1 inclusion body maturation and detoxification in yeast and mammalian cells.