Noncovalent antibody catenation on a target surface drastically increases the antigen-binding avidity
J. Song, B.-S. Jeong, S.-W. Kim, S.-B. Im, W. Cho, M.-J. Ahn, B.-H. Oh
This study demonstrates that genetically fusing a weakly homodimeric protein to antibodies enhances antigen-binding avidity by up to 5,120-fold through reversible catenation on antigen-rich surfaces.
bioRxiv · Jul 12, 2022Biophysics