BiophysicsbioRxiv
Noncovalent antibody catenation on a target surface drastically increases the antigen-binding avidity
J. Song, B.-S. Jeong, S.-W. Kim…·B.-H. Oh
This study demonstrates that genetically fusing a weakly homodimeric protein to antibodies enhances antigen-binding avidity by up to 5,120-fold through reversible catenation on antigen-rich surfaces.
DOI 10.7554/elife.81646