Author

W. Cho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Sharma· 2 shared K. J. Roberts· 2 shared Y. Cheng· 2 shared Y. Zhang· 2 shared A. Li· 1 shared A. Manglik· 1 shared A. Ralko· 1 shared B. An· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

A. Sharma

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PI(3,5)P2 Controls the Signaling Activity of Class I PI3K

J. Sun, J. Zalejski, S. Song, A. Sharma, W. Wang, Y. Hu, W.-T. Lo, P. Koch, J. Singh, I. Singaram, B. An, J. Zhao, L.-W. Gong, V. Haucke, R. Gao, W. Cho

This study identifies PI(3,5)P2 as a regulator of Class I PI3K activity by interacting with its p85 subunit, revealing a feedback mechanism that impacts cancer and tissue repair.

bioRxiv · Jan 25, 2023 · PreprintBiochemistry

Noncovalent antibody catenation on a target surface drastically increases the antigen-binding avidity

J. Song, B.-S. Jeong, S.-W. Kim, S.-B. Im, W. Cho, M.-J. Ahn, B.-H. Oh

This study demonstrates that genetically fusing a weakly homodimeric protein to antibodies enhances antigen-binding avidity by up to 5,120-fold through reversible catenation on antigen-rich surfaces.

bioRxiv · Jul 12, 2022Biophysics

Hedgehog pathway activation through conformational blockade of the Patched sterol conduit

Y. Zhang, W.-J. Lu, D. Bulkley, J. Liang, A. Ralko, K. J. Roberts, A. Li, W. Cho, Y. Cheng, A. Manglik, P. Beachy

This paper develops a nanobody agonist that activates the Hedgehog pathway by stabilizing an alternative conformation of Patched1, disrupting its sterol conduit and providing a new approach for transporter-related drug development.

bioRxiv · Sep 26, 2019Biophysics

Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched

Y. Zhang, D. P. Bulkley, K. J. Roberts, Y. Xin, D. Asarnow, A. Sharma, B. R. Myers, W. Cho, Y. Cheng, P. A. Beachy

This study presents a cryo-EM structure of Patched, revealing its structural similarity to RND transporters and suggesting a role in cholesterol transport.

bioRxiv · Jun 20, 2018Biophysics