Aerobic glycolysis supports hepatitis B virus biosynthesis through interaction between viral surface antigen and pyruvate kinase isoform M2
Y.-H. Wu, Y. Yang, C.-H. Chen, C.-J. Hsiao, T.-N. Li, K.-J. Liao, B.-S. Chen, L. Wang
This paper shows that HBV uses aerobic glycolysis to support its biosynthesis by interacting with PKM2, and that restoring PKM2 activity can reduce viral production and oncogenesis.
bioRxiv · Aug 10, 2020Microbiology