Author

Y.-H. Wu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:ecology & biodiversity· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

L. Wang· 3 shared T.-N. Li· 2 shared B. Li· 1 shared B. Zhang· 1 shared B.-S. Chen· 1 shared C.-C. Chien· 1 shared C.-H. Chen· 1 shared C.-h. Yang· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

L. Wang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Hydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2

R.-H. Wang, P.-R. Chen, Y.-T. Chen, Y.-C. Chen, Y.-H. Chu, C.-C. Chien, P.-C. Chien, S.-Y. Lo, Z.-L. Wang, M.-C. Tsou, S.-Y. Chen, G.-S. Chiu, W.-L. Chen, Y.-H. Wu, L. Wang, , K.-T. Lin

This study shows hydrogen sulfide destabilizes PKM2 tetramer through sulfhydration at cysteine 326, rewiring glucose metabolism and inhibiting tumor growth.

bioRxiv · Sep 2, 2023Cancer Biology

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses

Y.-f. Pan, H. Zhao, Q.-y. Gou, P.-b. Shi, J.-h. Tian, Y. Feng, K. Li, W.-h. Yang, D. Wu, G. Tang, B. Zhang, Z. Ren, S. Peng, G.-y. Luo, S.-j. Le, , M. Shi

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

bioRxiv · Aug 28, 2023 · PreprintEcology

Chemical-induced degradation of PreS2 mutant surface antigen reverses HBV- mediated hepatocarcinogenesis

J. Y. Yang, Y.-H. Wu, M. Y.-C. Pan, Y.-T. Chiou, R. K.-L. Lee, T.-N. Li, L. Wang

This study identifies ABT199 as an inhibitor of PreS2-LHBS that reverses HBV-mediated hepatocarcinogenesis through microautophagy-induced degradation.

bioRxiv · Jan 24, 2022 · PreprintMicrobiology

Aerobic glycolysis supports hepatitis B virus biosynthesis through interaction between viral surface antigen and pyruvate kinase isoform M2

Y.-H. Wu, Y. Yang, C.-H. Chen, C.-J. Hsiao, T.-N. Li, K.-J. Liao, B.-S. Chen, L. Wang

This paper shows that HBV uses aerobic glycolysis to support its biosynthesis by interacting with PKM2, and that restoring PKM2 activity can reduce viral production and oncogenesis.

bioRxiv · Aug 10, 2020Microbiology