Synthetic BiologyNature Chemical BiologyPeer-reviewed
DNA writing at a single genomic site enables lineage tracing and analog recording in mammalian cells
Theresa B. Loveless, Joseph H. Grotts, Mason W. Schechter…·Chang C. Liu
This paper introduces CHYRON, a DNA recorder that writes new DNA to track lineage and record cellular stimuli, demonstrating its ability to reconstruct lineage relationships and respond to stress signals.
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