Chromosomal instability drives continual flux in cancer genomes
Molly A Guscott, Audrey Lumeau, A. Gallagher, Nadeem Shaikh, Isabel N McNeill, Nathaniel V. Mon Père, David Gómez-Peregrina, Jovanna Maharaj, Joana de Reis Andrade, Tanya N. Soliman, René Wardenaar, Floris Foijer, Nelson Dusetti, Ben Werner, César Serrano, Sarah Elizabeth McClelland
This study shows that chromosomal instability (CIN) drives rapid genome changes in cancer cells, generating new copy number alterations each cell cycle and increasing genomic complexity.
bioRxiv · Oct 22, 2026 · PreprintGenomics