César Serrano

This study shows that chromosomal instability (CIN) drives rapid genome changes in cancer cells, generating new copy number alterations each cell cycle and increasing genomic complexity.

This study identifies MITF-regulated genes in GIST, showing its role in autophagy and extracellular vesicle secretion, with implications for tumor growth and metastasis.

This study shows that TAZ, not YAP1, is more critical for GIST progression and that targeting TAZ could be a better therapeutic strategy.

The paper tracks genome evolution in single-cell clones to reveal copy number alteration rates and features in cancer driven by chromosomal instability.