Author

Benjamin James Cossette

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Organism:non-human primate· 1

Frequent Co-Authors

Alexandra NeeseriD· 1 shared Anna M. RomanoviD· 1 shared Austin Cozzone· 1 shared Beatriz Goncalves· 1 shared Chelsea N. FriesiD· 1 shared Corrine A. NiefiD· 1 shared Darrell J. IrvineiD· 1 shared Duncan M. MorganiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioengineering

Alexandra NeeserORCID

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2 papers

Recent·Most cited

Designed nanofiber immunogens prime antibody responsesto diverse conformations of the HIV-1 fusion peptide

Chelsea N. Fries, Jui-Lin Chen, Nicole L. Votaw, Benjamin James Cossette, Emily F. Roe, Maria L. Dennis, Elizabeth J. Curvino, Luqman A. Issah, K. Lázár, Shamitha Shetty, Rachel Katz, Corrine A. Nief, Sallie R. Permar, Koen K. A. Van Rompay, Genevieve G. Fouda, Joel H. Collier

This paper introduces a designed nanofiber immunogen platform that primes antibodies with increased conformational tolerance toward HIV-1 fusion peptide, showing efficacy in mice and infant non-human primates.

bioRxiv · Oct 5, 2026 · PreprintBioengineering

Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells

Tomasz M. Grzywa, Alexandra Neeser, Ranjani Ramasubramanian, Anna M. Romanov, Ryan Tannir, Naveen K. Mehta, Benjamin James Cossette, Duncan M. Morgan, Beatriz Goncalves, Ina Sukaj, Elisa Bergaggio, Stephan Kadauke, Regina M. Myers, Luca Paruzzo, Guido Ghilardi, , Darrell J. Irvine

This study develops a method to generate optimized peptide ligands for CAR-T cell restimulation, demonstrating enhanced expansion and memory development in preclinical models.

Nature Biomedical Engineering · Aug 25, 2025Peer-reviewedBioengineering