Anna M. Romanov

DNA origami particles displaying eOD-GT8 with a synthetic T helper epitope gave antigen-focused germinal centers and expanded VRC01-class precursors in humanized mice after one immunization.

This study develops a method to generate optimized peptide ligands for CAR-T cell restimulation, demonstrating enhanced expansion and memory development in preclinical models.

This study shows that CD45 sequestration lowers T cell activation thresholds and enhances anti-tumor immunity when combined with IL-12 therapy in mouse models.

This study shows that combining slow antigen delivery and follicle-targeting adjuvants enhances germinal center B cell diversity and clonal expansion in mice.

This study shows that a two-dose extended priming vaccine regimen enhances humoral immune responses by synchronizing antigen delivery with germinal center dynamics.