NeurosciencebioRxivPreprint
Loss of Nuclear TDP-43 Impairs Lipid Metabolism in Microglia-Like Cells
Khushbu Kabra, Dallin Dressman, Ryan Talcoff…·Elizabeth M. Bradshaw
This study shows that loss of nuclear TDP-43 in microglia-like cells disrupts lipid metabolism, leading to increased lipid droplets, phagocytosis, and inflammation, which can be mitigated by DGAT inhibitors.
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