Changes In LXRα Phosphorylation Promote A Novel Diet-Induced Transcriptome That Alters The Transition From Fatty Liver To Steatohepatitis
Natalia Becares, Matthew C Gage, Lucia Martin-Gutierrez, Elina Shrestha, Rikah Louie, Benoit Pourcet, Oscar M Pello, Tu Vinh Luong, Saioa Goñi, Ning Liang, Cesar Pichardo, Hanne Røberg-Larsen, Vanessa Diaz, Knut R. Steffensen, Michael J. Garabedian, , Inés Pineda-Torra
This study shows that preventing LXRα phosphorylation at Ser196 reduces hepatic inflammation and fibrosis in mice on a high-fat diet, revealing a novel role for LXR phosphorylation in diet-induced transcriptome changes.
bioRxiv · Oct 30, 2017 · PreprintPathology