Isthmin-1 is a Key Regulator of Induced Pluripotent Stem Cell-Derived Cardiomyocytes Maturation through Activation of p53 Signaling
Haowen Guo, Ye Shi, Yang Shi, X Y Zhou, Bin Zhou, J W Tang, Faxiang Xu, Yanchen Guo, J Wang, Fang Chen, Dongming Su, Qi Li
This paper identifies ISM1 as a key regulator of iPSC-CM maturation through p53 activation, improving structural and metabolic features.
Journal of Molecular and Cellular Cardiology · Jul 11, 2026Peer-reviewedDevelopmental Biology