Xin Luo

This study analyzes T cell subsets, clonality, and trajectories in psoriasis using single-cell RNA and TCR sequencing, revealing tissue-specific and shared features of the T-cell repertoire.

The paper identifies bZIP transcription factors as key regulators of IL-2-induced Treg activation, linking chromatin accessibility changes to Th1/Th2 molecular phenotypes and metabolic pathways.

The paper compares single-cell regulomes of macaque and mouse neural progenitors with human data to identify evolutionary changes in cortex development.

The paper maps long-range enhancer networks in human, macaque, and mouse fetal cortex, showing human-specific enhancers and neuropsychiatric disorder-linked SNPs regulate gene expression during neurogenesis.

The paper presents a high-quality long-read genome assembly of the Chinese rhesus macaque and identifies ape-specific structural variants.

The paper uses whole genome trio sequencing to assess off-target effects of Cas9 editing in monkeys and finds no unexpected mutations.