J Wang

Isthmin-1 is a Key Regulator of Induced Pluripotent Stem Cell-Derived Cardiomyocytes Maturation through Activation of p53 Signaling

This paper identifies ISM1 as a key regulator of iPSC-CM maturation through p53 activation, improving structural and metabolic features.

A human intracranial map of consciousness returning from anesthesia

This study maps the electrophysiological changes in the human brain as consciousness returns from anesthesia, identifying key neural dynamics associated with the transition from unconsciousness to wakefulness.

Cholangiocyte RUNX1 Orchestrates Fibrogenic and Inflammatory Signaling to Drive Biliary Fibrosis

This study identifies RUNX1 as a key transcriptional regulator of fibrogenic and inflammatory signaling in cholangiocytes, showing its inhibition reduces biliary fibrosis and inflammation in models of cholangiopathy.

Scalable high-fidelity human vascularized cortical assembloids recapitulate neurovascular co-development and cell specialization

This paper introduces vascularized cortical assembloids (vCAs) that model neurovascular co-development and show improved cellular specialization and connectivity compared to standard cortical organoids.

NMDA Receptors Control Activity Hierarchy in Neural Network: Loss of Control in Hierarchy Leads to Learning Impairments, Dissociation, and Psychosis

This study quantifies neural activity hierarchy in the hippocampus and shows that NMDA receptor blockade disrupts hierarchy, leading to learning impairments and psychosis-like symptoms.