Yang Shi

This study identifies ITPKB as a regulator of NK cell desensitization, showing its inhibition enhances antitumor immunity in murine and human models.

This paper identifies ISM1 as a key regulator of iPSC-CM maturation through p53 activation, improving structural and metabolic features.

This study identifies EOLA1 as a mitochondrial protein critical for translation and heart function through interactions with 12S mt-rRNA and TUFM.

The paper identifies UXS1 as a selectively essential gene in UGDH-high cancer cells, showing it regulates UDP-GlcA levels to prevent toxicity and highlights it as a therapeutic target.

The paper identifies a point of irreversible commitment in granulocytic differentiation and shows how chromatin state dynamics and transcription factor feedback loops influence this decision.

This study identifies METTL15 as the enzyme responsible for m4C839 methylation in human 12S mt-rRNA and shows its critical role in mitochondrial function.

The paper identifies PCIF1 as the first human m6Am methyltransferase and shows it regulates gene expression by suppressing cap-dependent translation through m6Am methylation.